Trey Lance's season has come to an ill-fated end in Week 2.
The 49ers quarterback suffered a fractured ankle against the Seahawks that will require season-ending surgery, head coach Kyle Shanahan announced Sunday.
Jimmy Garoppolo entered the game for Lance and led San Francisco to a 27-7 victory over Seattle.
"It's unfortunate for him," Shanahan said after the game. "We're really hurting for him and we were really hoping to see a lot of him this year.
So, to see him have that bad of an injury to where he can't come back from it, you feel for him"
Lance was carted off the field with his right leg in an air cast after sustaining the injury in the first quarter.
Lance completed 2 of 3 passes for 30 yards and added 13 rushing yards prior to his exit.
After restructuring his contract to remain the 49ers' backup QB this offseason, Garoppolo came through in relief by going 13 for 21 for 154 yards passing and a touchdown.
Instead, Garoppolo will take over for a team he helped to the NFC Championship Game in 2021. The 49ers (1-1) are on the road in Week 3 to face the Broncos on Sunday night.